Nearly twenty years after the publication of Toxicity Testing in the 21st Century, the promise of toxicology transformation is no longer theoretical. New approach methods (NAMs) are expanding rapidly, offering more efficient, mechanistically informed, and less animal-intensive ways to evaluate chemical hazards and risks. What was once a vision is now a growing reality, supported by scientific innovation, collaborative validation efforts, and increasing regulatory interest in NAM-informed decision-making. The genetic toxicology community has been at the forefront of this transition. By advancing novel assays, high-content data streams, and fit-for-purpose frameworks for interpretation, the field has helped build the foundation for modernized testing strategies. Today, these approaches include transcriptomics, mechanism-based assays, sophisticated in vitro models, and emerging genomic tools such as error-corrected sequencing, alongside structured frameworks for data integration such as Adverse Outcome Pathways and quantitative approaches to evidence evaluation. The core questions being addressed in genetic toxicology are shared with ecotoxicology: which tools are fit for purpose, how should mechanistic data be integrated, and what is needed to move from innovation to implementation? Lessons from genetic toxicology, particularly around collaboration, context of use, and translational strategy, can help accelerate progress. This keynote will explore how these lessons can support the broader adoption of NAMs in ecotoxicology and beyond. It will argue that the challenge before us is no longer whether modern tools exist, but how we work together to carry them through the last mile into routine practice and real-world impact.