The African Centre for Aquatic Research and Education (ACARE) advances inclusive capacity-building in aquatic sciences through its African Women in Science program, designed to support early-career researchers focused on the African Great Lakes. As part of this initiative, I mentor a cohort of trainees in an intensive, two-week field and laboratory program hosted at the Experimental Lakes Area (ELA), a globally recognized freshwater research facility. During this presentation, I will outline the structure, objectives, and outcomes of the training program, which combines hands-on experimentation, data analysis, and collaborative research design in a real-world ecosystem context. Trainees engage directly with whole-lake experiments, gaining experience in limnological methods, experimental design, and interdisciplinary problem-solving, while also developing professional networks and leadership skills. A core component of the program is intentional cultural exchange. By creating space for participant to share their lived experiences, traditions, and perspectives, the program fosters connections that extend beyond scientific collaboration. This emphasis on learning about one another’s cultures strengthens trust, builds solidarity, and supports participants in relating to each other not only as scientists, but as women navigating diverse social and professional landscapes. I will discuss approaches tailored to diverse educational backgrounds, the importance of immersive field experiences in building scientific confidence, and the role of mentorship in supporting retention and advancement of women in aquatic sciences. Early outcomes suggest that short, intensive international training programs can significantly enhance technical skills, foster cross-cultural collaboration, and contribute to a more equitable global research community. The genetic toxicology community has been at the forefront of this transition. By advancing novel assays, high-content data streams, and fit-for-purpose frameworks for interpretation, the field has helped build the foundation for modernized testing strategies. Today, these approaches include transcriptomics, mechanism-based assays, sophisticated in vitro models, and emerging genomic tools such as error-corrected sequencing, alongside structured frameworks for data integration such as Adverse Outcome Pathways and quantitative approaches to evidence evaluation. The core questions being addressed in genetic toxicology are shared with ecotoxicology: which tools are fit for purpose, how should mechanistic data be integrated, and what is needed to move from innovation to implementation? Lessons from genetic toxicology, particularly around collaboration, context of use, and translational strategy, can help accelerate progress. This keynote will explore how these lessons can support the broader adoption of NAMs in ecotoxicology and beyond. It will argue that the challenge before us is no longer whether modern tools exist, but how we work together to carry them through the last mile into routine practice and real-world impact.